Dual Function of CD70 in Viral Infection: Modulator of Early Cytokine Responses and Activator of Adaptive Responses
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Correction: Dual Function of CD70 in Viral Infection: Modulator of Early Cytokine Responses and Activator of Adaptive Responses.
The role of the TNF family member CD70 in adaptive T cell responses has been intensively studied, but its function in innate responses is still under investigation. In this study, we show that CD70 inhibits the early innate response to murine CMV (MCMV) but is essential for the optimal generation of virus-specific CD8 T cells. CD70(-/-) mice reacted to MCMV infection with a robust type I IFN an...
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تاریخ انتشار 2014